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  • دکتری (1378)

    بافت شناسی وجنین شناسی

    دانشگاه تربیت مدرس، ایران

  • کارشناسی‌ارشد (1369)

    بافت شناسی و جنین شناسی

    دانشگاه تربیت مدرس،

  • کارشناسی (1366)

    زیست شناسی

    دانشگاه اصفهان، ایران

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  • آزمایشگاه فتومیکروسکوپ
  • آزمایشگاه اتاق سرد
  • آزمایشگاه بافت شناسی
  • آزمایشگاه تهیه نمونه برای مطالعات میکروسکوپ الکترونی (TEM)
  • آزمایشگاه جراحی
  • آزمایشگاه جنین شناسی
  • آزمایشگاه سالن تشریح
  • آزمایشگاه کشت سلول 1
  • آزمایشگاه کشت سلول 2
  • آزمایشگاه مطالعات ملکولی
  • آزمایشگاه میکروسکوپ نوری

مژده صالح نیا دکترای بافت شناسی و جنین شناسی هستم و در حال حاضر در گروه آناتومی، دانشکده علوم پزشکی، دانشگاه تربیت مدرس، تهران، ایران مشغول به کار هستم. تحقیقات من عمدتا بر روی انجماد تخمدان، بهبود کشت آزمایشگاهی بافت تخمدان و پیوند، استفاده از سلول‌های بنیادی مزانشیمی آندومتر انسان و بافت‌های سلول‌زدایی شده برای بازسازی آندومتر متمرکز هست. بیش از 176 مقاله در مجلات بین المللی و داخلی منتشر کرده ام.

ارتباط

رزومه

The Effect of Sodium Selenite on Expression of Mitochondrial Transcription Factor A during In Vitro Maturation of Mouse Oocyte

Tina Moshaashaee, Saeed Zavareh, Shahram Pourbeiranvand, Mojdeh Salehnia
Journal PapersAvicenna Journal of Medical Biotechnology , Volume 13 , Issue 2, 2021 March 1, {Pages 81-86 }

Abstract

Background: The aim of the present study was to investigate the effect of Sodium Selenite (SS) supplemented media on oocyte maturation, expression of mitochondrial transcription factor A (TFAM) and embryo quality.Methods: Mouse Germinal Vesicle (GV) oocytes were collected after administration of Pregnant Mare Serum Gonadotropin (PMSG); in experimental group 1, oocytes were cultured and then subjected for in vitro maturation in the absence of SS, and in experimental group 2, they were matured in vitro in the presence of 10 ng/ml of SS up to 16 hr. The control group included MII oocytes obtained from the fallopian tubes after ovarian stimulation with PMSG, followed by human chorionic gonadotropin. Then, the expression of TFAM in MII oocytes i

Human Mesenchymal Stem Cells being Encapsulated in Alginate/reduced Geraphen Oxide Improving Infarct Expansion, and Inducing Neovasculariziation Formation in Ischemic Myocardium

Nafiseh Baheiraei, Nasim Naderi, Mojdeh Salehnia, Behshid Ghadrdoost, Mehdi Razavi
Journal Papers , 2021 February 5, {Pages }

Abstract

Currently, one of the new therapeutic strategies is injection of hydrogel and cells to myocardial infarction (MI) patients, which has some limitations such as lack of electromechanical properties and neovascularization. In this study, we investigated the therapeutic potential of new electroactive hydrogel [Reduced graphene oxide (rGO)/Alginate (ALG)] encapsulated human bone marrow mesenchymal stem cell (BMSC) in different experimental groups. The study was done in rat model of chronic ischemic cardiomyopathy by ligating the left anterior descending coronary artery (LAD). Echocardiograms were analyzed at 4 and 8 weeks after MI induction.Experimental groups particularly (BMSC) encapsulated in rGO-ALG increased signi cantly improvement of frac

The Effects of Ovarian Encapsulation on Morphology and Expression of Apoptosis-Related Genes in Vitrified Mouse Ovary

Atefeh Shirazi Tehrani, Tahereh Mazoochi, Maryam Akhavan Taheri, Esmat Aghadavood, Mojdeh Salehnia
Journal PapersJournal of Reproduction & Infertility , Volume 22 , Issue 1, 2021 January 5, {Pages 23-31 }

Abstract

Background: The purpose of this study was to determine the effects of alginate hydrogel as a capsule to protect the ovary against possible detrimental effects of vitrification and warming on morphology and expression of apoptosis-related genes in the mouse ovary.Methods: In this experimental study, the ovaries from twenty-five female 8-week-old mice were divided into five groups of non-vitrified ovaries, vitrified ovaries, ovaries that were encapsulated with concentrations of 0.5, 0.75 and 1% of alginate hydrogel. The morphological study was performed using hematoxylin and eosin staining. Expression levels of apoptosis-associated genes were quantified in each group by real-time RT-PCR. The one-way ANOVA and post hoc test were used to analyz

The Effects of Ovarian Encapsulation on Morphology and Expression of Apoptosis-Related Genes in Vitrified Mouse Ovary

Atefeh Shirazi Tehrani, Tahereh Mazoochi, Maryam Akhavan Taheri, Esmat Aghadavood, Mojdeh Salehnia
Journal PapersJournal of Reproduction & Infertility , Volume 22 , Issue 1, 2021 January , {Pages 23 }

Abstract

Background:The purpose of this study was to determine the effects of alginate hydrogel as a capsule to protect the ovary against possible detrimental effects of vitrification and warming on morphology and expression of apoptosis-related genes in the mouse ovary.Methods:In this experimental study, the ovaries from twenty-five female 8-week-old mice were divided into five groups of non-vitrified ovaries, vitrified ovaries, ovaries that were encapsulated with concentrations of 0.5, 0.75 and 1% of alginate hydrogel. The morphological study was performed using hematoxylin and eosin staining. Expression levels of apoptosis-associated genes were quantified in each group by real-time RT-PCR. The one-way ANOVA and post hoc test were used to analyze

Follicular development and the expression of BAX and vascular endothelial growth factor in transplanted ovaries in uni-and Bilateral ovariectomized mice: An experimental study

Maryam Dehghan, Shirin Shahbazi, Mojdeh Salehnia
Journal PapersInternational Journal of Reproductive BioMedicine , Volume 19 , Issue 4, 2021 April 10, {Pages 361-370 }

Abstract

Ovarian transplantation is used to restore fertility potential and ovarian function in women with premature ovarian failure and in patients with cancer, and it can be performed using fresh or cryopreserved tissue in an autograft, allograft, and xenograft manner at orthotropic or heterotopic sites (1-4).Ischemia and degeneration of follicles are important factors, which should be considered during the transplantation of ovarian tissue and it can cause a decline in ovarian reserve and fertility potential (5-8). The vascular condition of the graft site plays a critical role in the reduction of ischemia. Therefore, angiogenesis in transplanted tissue and growth of the ovarian follicles depends on the graft site (5, 6, 8). Vascular endothelial g

Lysophosphatidic Acid Alters The Expression of Apoptosis Related Genes and miR-22 in Cultured and Autotransplanted Ovaries

M Dehghan, S Shahbazi, M Salehnia
Journal Papers , , {Pages }

Abstract

Characteristics of a decellularized human ovarian tissue created by combined protocols and its interaction with human endometrial mesenchymal cells

MN Sistani, S Zavareh, MR Valujerdi, M Salehnia
Journal Papers , , {Pages }

Abstract

In Vitro Implantation Model Using Human Endometrial SUSD2+ Mesenchymal Stem Cells and Myometrial Smooth Muscle Cells

M Rahimipour, M Jafarabadi, M Salehnia
Journal Papers , , {Pages }

Abstract

Effect of Lysophosphatidic Acid on the Vascular Endothelial Growth Factor Expression in Autotransplanted Mouse Ovaries Encapsulated in Sodium Alginate

M Dehghan, S Shahbazi, M Salehnia
Journal Papers , , {Pages }

Abstract

An efficient protocol for decellularization of the human endometrial fragments for clinical usage

Z Sargazi, S Zavareh, M Jafarabadi, M Salehnia
Journal Papers , , {Pages }

Abstract

Effect of Lysophosphatidic Acid on the Vascular Endothelial Growth Factor Expression in Autotransplanted Mouse Ovaries Encapsulated in Sodium Alginate

M Salehnia
Journal Papers , , {Pages }

Abstract

Reduced graphene oxide facilitates biocompatibility of alginate for cardiac repair (vol 35, pg 363, 2020)

KN Hajishoreh, N Baheiraei, N Naderi, M Salehnia
Journal Papers , , {Pages }

Abstract

Folliculogenesis-Associated Genes Expression in Human Vitrified Ovarian Tissue after Xenotransplantation in γ-Irradiated Mice.

Mofarahe Z Shams, Novin M Ghaffari, M Salehnia
Journal PapersCell journal , Volume 22 , Issue 3, 2020 October , {Pages 350 }

Abstract

Objective: Autograft transplantation of vitrified cortical ovarian tissue is an acceptable clinical technique for fertility preservation in women. Xenograft transplantation into animal models could be useful for evaluating the safety of human vitrified ovarian tissue. This study targeted to evaluate impact of vitrification on expression of the genes associated with folliculogenesis after xenograft transplantation of human vitrified ovarian tissue to γ-irradiated mice. Materials and Methods: In this experimental study, ovarian biopsies were gathered from six transsexual persons. The cortical section of ovarian biopsies was separated and chopped into small pieces. These pieces were randomly divided into vitrified and non-vitrified groups. In

Supplementation of Culture Media with Lysophosphatidic Acid Improves The Follicular Development of Human Ovarian Tissue after Xenotransplantaion into The Back Muscle of γ

Zeynab Mohammadi, Nasim Hayati Roodbari, Kazem Parivar, Mojdeh Salehnia
Journal PapersCell journal , Volume 22 , Issue 3, 2020 October , {Pages 358 }

Abstract

Objective: The aim of the present study was to evaluate the effects of lysophosphatidic acid (LPA) supplementation of human ovarian tissue culture media on tissue survival, follicular development and expression of apoptotic genes following xenotransplantation.Materials and Methods: In this experimental study, human ovarian tissue was collected from eight normal female to male transsexual individuals and cut into small fragments. These fragments were vitrified-warmed and cultured for 24 hours in the presence or absence of LPA, then xenografted into back muscles of γ-irradiated mice. Two weeks post-transplantation the morphology of the recovered tissues were evaluated by hematoxylin and eosin staining. The expression of genes related to apop

Supplementation of Culture Media with Lysophosphatidic Acid Improves The Follicular Development of Human Ovarian Tissue after Xenotransplantaion into The Back Muscle of γ

Zeynab Mohammadi, Nasim Hayati Roodbari, Kazem Parivar, Mojdeh Salehnia
Journal Papers , 2020 September 1, {Pages }

Abstract

Objective: The aim of the present study was to evaluate the effects of lysophosphatidic acid (LPA) supplementation of human ovarian tissue culture media on tissue survival, follicular development and expression of apoptotic genes following xenotransplantation.Materials and Methods: In this experimental study, human ovarian tissue was collected from eight normal female to male transsexual individuals and cut into small fragments. These fragments were vitrified-warmed and cultured for 24 hours in the presence or absence of LPA, then xenografted into back muscles of γ-irradiated mice. Two weeks post-transplantation the morphology of the recovered tissues were evaluated by hematoxylin and eosin staining. The expression of genes related to apop

Reduced graphene oxide facilitates biocompatibility of alginate for cardiac repair

Negar Karimi Hajishoreh, Nafiseh Baheiraei, Nasim Naderi, Mojdeh Salehnia
Journal PapersJournal of Bioactive and Compatible Polymers , Volume 35 , Issue 05-Apr, 2020 July , {Pages 363-377 }

Abstract

The benefits of combined cell/material therapy appear promising for myocardial infarction treatment. The safety of alginate, along with its excellent biocompatibility and biodegradability, has been extensively investigated for cardiac tissue engineering. Among graphene-based nanomaterials, reduced graphene oxide has been considered as a promising candidate for cardiac treatment due to its unique physicochemical properties. In this study, the reduced graphene oxide incorporation effect within alginate hydrogels was investigated for cardiac repair application. Reduced graphene oxide reinforced alginate properties, resulting in an increase in gel stiffness. The cytocompatibility of the hydrogels prepared with human bone marrow–derived mesenc

Morphometric Analysis of Offspring Ovary in Mice Following Oxaliplatin Treatment during Perinatal Period Using Stereology Technique

Moslem Dahmardeh, Javad Sadeghinezhad, Zahra Tootian
Journal PapersJournal of Ardabil University of Medical Sciences , Volume 20 , Issue 1, 2020 October 10, {Pages 32-48 }

Abstract

Background & objectives: Oxaliplatin is a third-generation of platinum drug which is the main therapeutic agent for the treatment of colorectal cancer. Oxaliplatin not only inhibits DNA replication but also transcription and also induces apoptosis or necrosis in cancer cells and rapidly dividing cell lines. Although it is widely used clinically, there is no enough information regarding its effect on ovarian structure. This study was designed to determine morphometric features of 30-and 60-day-old offspring ovaries using precise and unbiased stereological technique following administration of oxaliplatin during perinatal period in mice.Methods: In the present experimental study, 32 adult female mice were used for experimental (pre-pregnant,

The Effect of Sodium Selenite on Apoptotic Gene expression and development of In Vitro Cultured Mouse Oocytes in Comparison with In Vivo Obtained Oocytes

Maziar Malekzadeh Kebria, Mojdeh Salehnia, Saeed Zavareh, Said Moazzeni
Journal PapersVeterinary Research Forum , 2020 September 29, {Pages }

Abstract

In vitro maturation (IVM) of oocytes is widely used in assisted reproduction technologies whereas the obtained results are not efficient. This study was aimed to improve the in vitro oocyte maturation and its development by supplementation of culture media with sodium selenite (SS). Moreover, the effects of SS on the expression of oocytes apoptosis-related genes was assessed. In this study, male and female NMRI mice were used and their germinal vesicle (GV) oocytes were collected and cultured with SS (experimental group) and without SS (control group). Also collected metaphase II oocytes (MII) from fallopian tube considered as in vivo group. After in vitro culture, the oocytes were evaluated for nuclear maturation. Some of the MII oocytes w

Effect of Oxaliplatin on sperm parameters of 60 days old offspring during pre-pregnancy, pregnancy and lactation period in mice

Moslem Dahmardeh, Javad Sadeghinezhad, Zahra Tootian, Mojdeh Salehnia
Journal PapersJournal of Gorgan University of Medical Sciences , Volume 22 , Issue 1, 2020 April 10, {Pages 50-56 }

Abstract

Methods: In this experimental study, 32 female NMRI mature mice were randomly allocated into 4 groups. Animals in control group were received 0.2 ml saline intraperitoneally (IP) during 21 days of pre-pregnany, pregnancy and lactation periods. Animals in experimental groups including pre-pregnant, pregnant and lactation groups were received 3 mg/kg oxaliplatin trice a week IP during 21 days before mating, during pregnancy and lactation periods, respectively. At the 60th postnatal day, all the male offspring were euthanized and sperm samples were obtained. Analysis of sperm parameters including count, motility, vitality, maturation and DNA integrity was done.Results: Sperm count, motility and DNA integrity were significantly reduced in all t

Supplementation of culture media with lysophosphatidic acid improves the follicular development of human ovarian tissue after xenotransplantaion into the back muscle of γ …

Z Mohammadi, NH Roodbari, K Parivar, M Salehnia
Journal Papers , , {Pages }

Abstract

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دروس نیمسال قبل

  • دكتري
    سلولهاي بنيادي ( واحد)
    دانشکده علوم پزشکی، گروه علوم تشريح
  • دكتري
    سلولهاي بنيادي ( واحد)
  • كارشناسي ارشد
    بافت شناسي عمومي ( واحد)
  • كارشناسي ارشد
    بافت شناسي عمومي ( واحد)
  • 1397
    باقري, سيد محمد جعفر
    نقش سلول هاي بنيادي مزانشيمي آندومتر انساني در سيستم هاي كشت ايستا و نيمه پويا بر تكوين كمپلكس كومولوس تخمك كايمريك
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